منابع مشابه
LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct binding of KASH and SUN in the perinuclear space. Thereby, molecular tethers are formed that can transmit forces for chromosome movements, nuclear migration, and anchorage. W...
متن کاملKASH and SUN proteins
KASH and SUN proteins Quick guides at-bat, including which fielders were involved, and so on. At that point, I was amused to see that my friend Kyle was also keeping score, but that he marked every at-bat with a simple and uninformative ‘X’ when each batter was retired; consequently, his whole data sheet on the opposing team was just one string of Xs after another. Although I was feeling the su...
متن کاملIt Takes KASH to Hitch to the SUN
Observations stretching back more than two decades have suggested that nuclei and nuclear components are mechanically coupled to the cytoskeleton. In multicellular organisms, this mechanical coupling may extend beyond the plasma membrane to the extracellular matrix and adjacent cells. More recently, studies on a variety of human diseases associated with defects in nuclear envelope (NE) proteins...
متن کاملA new SUN role – no KASH required?
In eukaryotic cells, a close physical association between the microtubule-organising centre (MTOC) and the nucleus is essential, and its disruption leads to severe cellular abnormalities. MTOC–nucleus attachment is maintained by SUN and KASH proteins, which are found in the inner and outer nuclear membranes, respectively, and typically interact to form nuclear-envelope-spanning LINC complexes. ...
متن کاملThe opisthokont NE bridges formed by SUN and KASH proteins
The nuclear envelope (NE) is a double membrane system enclosing the genome of eukaryotes. Besides nuclear pore proteins, which form channels at the NE, nuclear membranes are populated by a collection of NE proteins that perform various cellular functions. However, in contrast to well-conserved nuclear pore proteins, known NE proteins share little homology between opisthokonts and plants. Recent...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2013
ISSN: 1949-1034,1949-1042
DOI: 10.4161/nucl.24088